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Daily fractions to abdomenAdminister 8 mg PO 1-2 hr before radiotherapyadminister subsequent doses every 8 hr after first dose each day radiotherapy is given.

In vitro metabolism studies have shown that ondansetron is a substrate for human hepatic cytochrome P-450 enzymesincluding CYP1A2CYP2D6and CYP3A4In terms of overall ondansetron turnoverCYP3A4 played the predominant roleBecause of the multiplicity of metabolic enzymes capable of metabolizing ondansetronit is likely that inhibition or loss of one enzymee.gCYP2D6 genetic deficiencywill be compensated by others and may result in little change in overall rates of ondansetron elimination.

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