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Th man oal LD 50 ATAN (tihxyphnidyl) has bn potd tb 365 mg/kg (ang, 325 t410 mg/kg) in mic and 1660 mg/kg (1420 t1940 mg/kg) in ats. At a dos 40 mg/kg, dogs hav xhibitd msis, stlssnss ollowd by dowsinss, quilibium distubancs, and mydiasis.
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Th siz and quncy th ATAN (tihxyphnidyl) dos ndd tcontol xtapyamidal actions tcommonly mployd tanquilizs, notably th phnothiazins, thioxanthns, and butyophnons, must b dtmind mpiically. Th total daily dosag usually angs btwn 5 and 15 mg although, in som cass, ths actions hav bn satisactoily contolld with as littl as 1 mg daily. It may b advisabl tcommnc thapy with a singl 1 mg dos. I th xtapyamidal manistations a not contolld in a w hous, th subsqunt doss may b pogssivly incasd until satisactoy contol is achivd. Satisactoy contol may somtims b mapidly achivd by tmpoaily ducing th dosag th tanquiliz whn instituting ATAN (tihxyphnidyl) thapy and thn adjusting th dosag both dugs until th dsid ataactic ct is taind without onst xtapyamidal actions.
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