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The times to peak concentrations for the erythrohydrobupropion and threohydrobupropion metabolites are similar to that of the hydroxybupropion metabolite.

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Coadministration may cause serotonin syndrome Do not use concomitantly or initiate bupropion within 14 days of stopping an MAOI Converselyat least 14 days should be allowed after stopping bupropion before starting an MAOI antidepressant Starting bupropion in a patient who is being treated with linezolid or IV methylene blue is contraindicated because of an increased risk of serotonin syndrome If linezolid or IV methylene blue must be administereddiscontinue bupropion immediately and monitor for CNS toxicitymay resume 24 hr after last linezolid or methylene blue dose or after 2 weeks of monitoringwhichever comes first.

Bupropion hydrobromide extended-release tablets are intended for oral use onlyinhalation of crushed tablets or injection of dissolved bupropion reportedseizures and/or cases of death reported when administered intranasally or by parenteral injection.

Risk of mydriasismay trigger angle closure attack in patients with angle closure glaucoma with anatomically narrow angles without a patent iridectomyuse caution.

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in a lactation study of ten women, levels of orally dosed bupropion and its active metabolites were measured in expressed milk.

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