Caution them about driving and any other potentially hazardous activity while taking clozaril see warnings and precautions .
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Liver problemsnauseaupper stomach painloss of appetitetirednessconfusionunusual bleedingdark urineclay-colored stoolsjaundiceyellowing of the skin or eyes
A gradual reduction in dose by steps of 12.5 mg over a period of at least one weekpreferably twois recommended.
Clozaril can cause agranulocytosisThe incidence of agranulocytosis and the fatality rate in those developing agranulocytosis have decreased markedly since the institution of white blood cellWBCcounts and absolute neutrophil countANCmonitoringThe following precautionary measures are therefore mandatory and should be carried out in accordance with official recommendations.
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