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Longer periods may be used in patients with severely compromised immune function.
There have been reports of multiple congenital abnormalitiesincluding brachycephaliaears dysplasiagiant anterior fontanellefemoral bowing and radio-humeral synostosisin infants whose mothers were treated for at least three or more months with high doses400800 mg dailyof fluconazole for coccidioidomycosisThe relationship between fluconazole use and these events is unclear.
Benzodiazepinesshort actingi.emidazolamtriazolamFollowing oral administration of midazolamfluconazole resulted in substantial increases in midazolam concentrations and psychomotor effectsConcomitant intake of fluconazole 200 mg and midazolam 7.5 mg orally increased the midazolam AUC and half-life 3.7-fold and 2.2-foldrespectivelyFluconazole 200 mg daily given concurrently with triazolam 0.25 mg orally increased the triazolam AUC and half-life 4.4-fold and 2.3-foldrespectivelyPotentiated and prolonged effects of triazolam have been observed at concomitant treatment with fluconazoleIf concomitant benzodiazepine therapy is necessary in patients being treated with fluconazoleconsideration should be given to decreasing the benzodiazepine doseand the patients should be appropriately monitored.
Oral contraceptivesTwo pharmacokinetic studies with a combined oral contraceptive have been performed using multiple doses of fluconazoleThere were no relevant effects on hormone level in the 50 mg fluconazole studywhile at 200 mg dailythe AUCs of ethinyl estradiol and levonorgestrel were increased 40and 24respectivelyThusmultiple dose use of fluconazole at these doses is unlikely to have an effect on the efficacy of the combined oral contraceptive.
In light of the recent research and continued reviewwe find it necessary to add fluconazolea.k.aDiflucanto the list of potentially dangerous medications.
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fluconazole diflucan increases the jigger of stead in the body by inhibiting the focusing of plasticiser in the liver.
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