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HemorrhageIncreased PT/INR due to interaction between coumarin anticoagulants and CasodexSerious bleeding reportedsee Warnings and Precautions5.2
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This drug may make you dizzy or drowsyAlcohol or marijuana can make you more dizzy or drowsyDo not driveuse machineryor do anything that needs alertness until you can do it safelyLimit alcoholic beveragesTalk to your doctor if you are using marijuana.
Renal side effects including new or worsened renal insufficiencyas measured by elevated BUN and creatininehave been reportedRef]
Casodex 150 mg daily is not approved for use in patients with M1 cancer of the prostateBased on an interim analysis of the two trials for survivalthe Data Safety Monitoring Board recommended that Casodex treatment be discontinued in the M1 patients because the risk of death was 25HR 1.2595CI 0.87 to 1.81and 31HR 1.3195CI 0.97 to 1.77higher in the Casodex treated group compared to that in the castrated grouprespectively.
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