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Chloroquine-induced retinal toxicity was first described in 1959 and the retinal toxic effects of hydroxychloroquine were later described in 1967 3, 4 .

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Before using chloroquine for prophylaxisit should be ascertained whether chloroquine is appropriate for use in the region to be visited by the travelerChloroquine should not be used for treatment of Pfalciparum infections acquired in areas of chloroquine resistance or malaria occurring in patients where chloroquine prophylaxis has failed.

All patients on long-term therapy with this preparation should be questioned and examined periodicallyincluding testing knee and ankle reflexesto detect any evidence of muscular weaknessIf weakness occursdiscontinue the drug.

Each tablet contains 500 mg of chloroquine phosphate USPequivalent to 300 mg chloroquine base.

Take a missed dose as soon as you think about itIf it is close to the time for your next doseskip the missed dose and go back to your normal timeDo not take 2 doses at the same time or extra doses.

Chloroquine is still the drug of choice for sensitive malaria parasites although ACTs are used increasinglyChloroquine is therefore used widely for PvivaxPmalariae and Povalebut except in a very few areas has been replaced for Pfalciparum treatmentThe time-honoured oral chloroquine regimen of 25 mg base/kg spread over 3 days10105 or 10555 mg/kg at 24-hour intervalscan be condensed into 36 hours of drug administrationThere is no role today for parenteral chloroquineChloroquine is considered safe in pregnancy and in young children.

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electroretinograms of children born to mothers treated with hydroxychloroquine during pregnancy and breast-feeding comment on the article by costedoat-chalumeau et al.


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