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Patients suspected of having signs or symptoms of lactic acidosis must seek emergency medical help.

Drugs that cause blood glucose levels to increase may diminish the effectiveness of Glucovance therapyWhen these drugs are stoppedpatients should be closely observed for signs of low blood glucoseThese drugs include thiazidesother diureticscorticosteroidsphenothiazinesthyroid medicationsestrogensbirth control pillsphenytoinDilantinnicotinic acidsympathomimeticscalcium channel blockersCCBsand isoniazidNydrazidCimetidineTagametby decreasing the elimination of metformin from the bodycan increase the amount of metformin in the blood by 40This may increase the frequency of side effects from metforminContrast media used for radiological procedures may reduce kidney function which reduces elimination of metforminleading to increased concentrations of metformin in the bloodMetformin should be stopped 48 hours before and after use of contrast mediaAlcohol consumption increases the effect of metformin on lactate productionincreasing the risk of lactic acidosisCertain drugs may increase the blood glucose lowering actions of glyburideIt is possible that hypoglycemialow blood glucoseand symptoms from hypoglycemia may resultSuch drugs include nonsteroidal anti-inflammatory medicationsNSAIDssalicylatessulfonamideschloramphenicolprobenecidcoumarinsciprofloxacinCipromonoamine oxidase inhibitorsMAOIsoral miconazoleand beta-adrenergic blockersCoadministration of glyburide with bosentanTracleermay cause an abnormal increase in liver enzymesThereforeconcomitant use of these agents is not recommendedColesevelamWelcholmay reduce blood levels of glyburidePatients are advised to take glyburide 1 hour before or 4 hours after colesevelam administration to minimize the risk of their interaction.

Drugs that cause blood glucose levels to increase may diminish the effectiveness of Glucovance therapyWhen these drugs are stoppedpatients should be closely observed for signs of low blood glucoseThese drugs include thiazidesother diureticscorticosteroidsphenothiazinesthyroid medicationsestrogensbirth control pillsphenytoinDilantinnicotinic acidsympathomimeticscalcium channel blockersCCBsand isoniazidNydrazidCimetidineTagametby decreasing the elimination of metformin from the bodycan increase the amount of metformin in the blood by 40This may increase the frequency of side effects from metforminContrast media used for radiological procedures may reduce kidney function which reduces elimination of metforminleading to increased concentrations of metformin in the bloodMetformin should be stopped 48 hours before and after use of contrast mediaAlcohol consumption increases the effect of metformin on lactate productionincreasing the risk of lactic acidosisCertain drugs may increase the blood glucose lowering actions of glyburideIt is possible that hypoglycemialow blood glucoseand symptoms from hypoglycemia may resultSuch drugs include nonsteroidal anti-inflammatory medicationsNSAIDssalicylatessulfonamideschloramphenicolprobenecidcoumarinsciprofloxacinCipromonoamine oxidase inhibitorsMAOIsoral miconazoleand beta-adrenergic blockersCoadministration of glyburide with bosentanTracleermay cause an abnormal increase in liver enzymesThereforeconcomitant use of these agents is not recommendedColesevelamWelcholmay reduce blood levels of glyburidePatients are advised to take glyburide 1 hour before or 4 hours after colesevelam administration to minimize the risk of their interaction.

Learn about type 2 diabetes warning signssymptomsdiagnosisand treatment optionsRead how diet and exercise can help manage.

This medication can cause changes in the menstrual cyclepromote ovulationand increase the risk of becoming pregnantConsult your doctor or pharmacist about the use of reliable birth control while using this medication.

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