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Important information about some of the ingredients of nicotinell menthe fraicheur 2 mg sans sugar, medicated chewing gum .

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The risk of overdose is small as nausea and vomiting usually occurs at an early stage with excessive nicotine intake.

Nicotinell patches should preferably be used in conjunction with a behavioural support programme.

Talk to your doctor and ask for his/her advice before using Nicotinell Chewing Gum if:

METHODSThree pharmacokineticPKone safety and two efficacy studies were carried out with Nicotinell lozengesPK trials were1a single-dosethree-way crossover study comparing 1 and 2 mg lozenges with 2 mg nicotine gum2a multiple-dosetwo-way crossover study comparing 1 mg lozenge with 2 mg gum3a multiple-dosethree-way crossover study comparing 1 and 2 mg lozenges with 4 mg gumSafety trial4a single dose study to assess the safety of swallowing up to 12 lozenges containing 1 mg nicotineEfficacy trialstwo efficacy studies in5France and6the USAincluding more than 900 smokers followed-up for up to one yearconducted with the 1 mg lozenge.

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