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If your symptoms or health problems do not get better or if they become worsecall your doctorDo not share your drugs with others and do not take anyone else’s drugsKeep a list of all your drugsprescriptionnatural productsvitaminsOTCwith youGive this list to your doctorTalk with the doctor before starting any new drugincluding prescription or OTCnatural productsor vitaminsThis medicine comes with an extra patient fact sheet called a Medication GuideRead it with careRead it again each time Ponstelmefenamic acidis refilledIf you have any questions about Ponstelmefenamic acidplease talk with the doctorpharmacistor other health care providerIf you think there has been an overdosecall your poison control center or get medical care right awayBe ready to tell or show what was takenhow muchand when it happened.

Known hypersensitivitye.ganaphylactic reactions and serious skin reactionsto mefenamic acid or any components of the drug productsee WARNINGSAnaphylactic ReactionsSerious Skin ReactionsHistory of asthmaurticariaor other allergic-type reactions after taking aspirin or other NSAIDsSeveresometimes fatalanaphylactic reactions to NSAIDs have been reported in such patientssee WARNINGSAnaphylactic ReactionExacerbation of Asthma Related to Aspirin SensitivityIn the setting of coronary artery bypass graftCABGsurgerysee WARNINGSCardiovascular Thrombotic Events

If you have any of these other conditionsyou may need a dose adjustment or special tests to safely use this medication:

Observational studies conducted in the Danish National Registry have demonstrated that patients treated with NSAIDs in the post-MI period were at increased risk of reinfarctionCV-related deathand all-cause mortality beginning in the first week of treatmentIn this same cohortthe incidence of death in the first year post-MI was 20 per 100 person years in NSAID-treated patients compared to 12 per 100 person years in non-NSAID exposed patientsAlthough the absolute rate of death declined somewhat after the first year post-MIthe increased relative risk of death in NSAID users persisted over at least the next four years of follow-up.

There is no consistent evidence that concurrent use of aspirin mitigates the increased risk of serious CV thrombotic events associated with NSAID useThe concurrent use of aspirin and an NSAIDsuch as mefenamic acidincreases the risk of serious gastrointestinalGIeventssee WARNINGSGastrointestinal BleedingUlcerationand Perforation

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