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Combination treatment with metformin is associated with an increased risk of hypoglycaemia.
Avoid drinking alcoholIt lowers blood sugar and may interfere with your diabetes treatment.
Do not throw away any medicines via wastewater or household wasteAsk your pharmacist how to throw away medicines you no longer useThese measures will help protect the environment.
No clinical studies have been conducted in patients with hepatic insufficiency.
In vitro data indicate that repaglinide is metabolised predominantly by CYP2C8but also by CYP3A4Clinical data in healthy volunteers support CYP2C8 as being the most important enzyme involved in repaglinide metabolism with CYP3A4 playing a minor rolebut the relative contribution of CYP3A4 can be increased if CYP2C8 is inhibitedConsequently metabolismand by that clearance of repaglinidemay be altered by substances which influence these cytochrome P-450 enzymes via inhibition or inductionSpecial care should be taken when inhibitors of both CYP2C8 and 3A4 are co-administered simultaneously with repaglinide.
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