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In a thorough QT studyCelexa was found to be associated with a dose-dependent increase in the QTc intervalsee WARNINGSQT-Prolongation And Torsade de Pointes
Celexacitalopram HBrshould be administered at an initial dose of 20 mg once dailywith an increase to a maximum dose of 40 mg/day at an interval of no less than one weekDoses above 40 mg/day are not recommended due to the risk of QT prolongationAdditionallythe only study pertinent to dose response for effectiveness did not demonstrate an advantage for the 60 mg/day dose over the 40 mg/day dose.
Administration of 40 mg/day Celexa for 21 days did not affect the pharmacokinetics of warfarina CYP3A4 substrateProthrombin time was increased by 5the clinical significance of which is unknown.
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