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3 6 during the initiation of febuxostat therapy, adverse effects from concurrent use of colchicine nausea, vomiting, and, rarely, neutropenia or nonsteroidal anti-inflammatory drugs nsaids, gastrointestinal distress, ulcers, and renal dysfunction are possible.

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A 4-fold reduction in colchicine dosage is recommended when co-administered with a P-gp inhibitor and/or a strong CYP3A4 inhibitorA 2-fold reduction in colchicine dosage is recommended when co-administered with a moderate CYP3A4 inhibitor.

For prophylaxis of gout flaresthe recommended dosage of colchicine capsules is 0.6 mg once or twice dailyThe maximum dose is 1.2 mg per day.

Take colchicine capsules exactly as your healthcare provider tells you to take itColchicine capsules can be taken with or without foodIf you take too much colchicine capsulescall your healthcare provider or go to the nearest hospital emergency room right awayDo not stop taking colchicine capsules unless your healthcare provider tells you toIf you miss a dose of colchicine capsulestake it as soon as you rememberIf it is almost time for your next doseskip the missed doseTake the next dose at your regular timeDo not take 2 doses at the same timeIf you have a gout flare while taking colchicine capsulestell your healthcare provider.

Colchicine consists of pale yellow scales or powderit darkens on exposure to lightColchicine is soluble in waterfreely soluble in alcoholand slightly soluble in ether.

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