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Persons who are using drugs that suppress the immune system are more susceptible to infections than healthy individualsChickenpox and measlesfor examplecan have a more serious or even fatal course in susceptible children or adults using corticosteroidsIn such children or adults who have not had these diseases or been properly immunizedparticular care should be taken to avoid exposureHow the doserouteand duration of corticosteroid administration affect the risk of developing a disseminated infection is not knownThe contribution of the underlying disease and/or prior corticosteroid treatment to the risk is also not knownIf a patient is exposed to chickenpoxprophylaxis with varicella zoster immune globulinVZIGmay be indicatedIf a patient is exposed to measlesprophylaxis with pooled intramuscular immunoglobulinIGmay be indicatedSee the complete prescribing information for VZIG and IGIf chickenpox developstreatment with antiviral agents may be considered.

Fluticasone propionate did not induce gene mutation in prokaryotic or eukaryotic cells in vitroNo significant clastogenic effect was seen in cultured human peripheral lymphocytes in vitro or in the mouse micronucleus test.

Because clinical trials are conducted under widely varying conditionsadverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice.

FLONASE Nasal Spray is for use in your nose onlyDo not spray it in your eyes or mouthChildren should use FLONASE Nasal Spray with an adult’s helpas instructed by the child’s healthcare providerUse FLONASE Nasal Spray exactly as your healthcare provider tells youDo not use FLONASE Nasal Spray more often than prescribedFLONASE Nasal Spray may take several days of regular use for your rhinitis symptoms to get betterIf your symptoms do not improve or get worsecall your healthcare providerYou will get the best results if you keep using FLONASE Nasal Spray regularly each day without missing a doseAfter you begin to feel betteryour healthcare provider may decrease your doseDo not stop using FLONASE Nasal Spray unless your healthcare provider tells you to do so.

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