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Electrolyte imbalances are common in patients with renal impairmentwith or without diabetesand should be addressedIn a clinical study conducted in type 2 diabetic patients with nephropathythe incidence of hyperkalaemia was higher in the group treated with losartan as compared to the placebo groupsee section 4.8Thereforethe plasma concentrations of potassium as well as creatinine clearance values should be closely monitoredespecially patients with heart failure and a creatinine clearance between 30-50 ml/min should be closely monitored.
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Following oral administrationplasma concentrations of losartan and its active metabolite decline polyexponentiallywith a terminal half-life of about 2 hours and 6-9 hoursrespectivelyDuring once-daily dosing with 100 mgneither losartan nor its active metabolite accumulates significantly in plasma.
Overallthere was a dose-responseThe dose-response relationship became very obvious in the low dose group compared to the middle dose groupperiod I6.2 mmHg vs11.65 mmHgbut was attenuated when comparing the middle dose group with the high dose groupperiod I11.65 mmHg vs12.21 mmHgThe lowest doses studied2.5 mg and 5 mgcorresponding to an average daily dose of 0.07 mgkgdid not appear to offer consistent antihypertensive efficacy.
Dizziness or lightheadedness may occur as your body adjusts to the medicationIf any of these effects persist or worsentell your doctor or pharmacist promptly.
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