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The decrease in clearance and subsequent increase in exposure to dutasteride in the presence of verapamil and diltiazem is not considered to be clinically significant.

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Dutas may rarely cause serious side effects such assudden numbnessweaknesssevere headachechest paininability to get an erectilelower sdrivelower sperm countbenign liver tumorrestlessnesstirednesslow moodswelling breastweakening of the bonesand liver cancer.

SmokingSmoking contributes to the development of erectile dysfunctionmainly because it increases the effects of other blood vessel disordersincluding high blood pressure and atherosclerosis.

Surgery for prostate diseasesRadical prostatectomy for prostate cancer often causes loss of sexual function but nerve-sparing surgical procedures reduce the risk of edradiation treatments for prostate cancer also cause erectile dysfunctionsurgical treatments for BPH can also cause edbut this complication is relatively uncommon.

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distribution pharmacokinetic data following single and repeat oral doses show that dutasteride has a large volume of distribution 300-500 l .

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