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Imuran is usually taken in combination with other medicines such as corticosteroids or other immunosuppressive drugs.

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Your white blood cell count and your weight will determine the dose that is prescribedThe starting dose is low and is slowly increasedImuran is generally taken once or twice a dayIt is available in 50 mgtabletswhich may be easily broken in half if necessary.

Patients being started on IMURAN should be informed of the necessity of periodic blood counts while they are receiving the drug and should be encouraged to report any unusual bleeding or bruising to their physicianThey should be informed of the danger of infection while receiving IMURAN and asked to report signs and symptoms of infection to their physicianCareful dosage instructions should be given to the patientespecially when IMURAN is being administered in the presence of impaired renal function or concomitantly with allopurinolsee DRUG INTERACTIONS subsection and DOSAGE AND ADMINISTRATIONPatients should be advised of the potential risks of the use of IMURAN during pregnancy and during the nursing periodThe increased risk of malignancy following therapy with IMURAN should be explained to the patient.

Drugs which may affect leukocyte productionincluding cotrimoxazolemay lead to exaggerated leukopeniaespecially in renal transplant recipients.

19Coulam CBMoyer TPJiang NSet alBreast-feeding after renal transplantationTransplant Proc198214605-609.

3McLeod HLSiva CThe thiopurine S-methyltransferase gene locusimplications for clinical pharmacogenomicsPharmacogenomics2002;3:89-98.

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