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In a randomizedparallel trial comparing placebo with 300 and 500 mg/day of LAMICTALsome of the more common drug-related adverse reactions were dose relatedsee Table 9

Nausea sleeping trouble sleepiness or extreme tiredness back pain rash runny nose stomach pain dry mouth.

Data from in vitro studies indicate that lamotrigine is approximately 55bound to human plasma proteins at plasma lamotrigine concentrations from 1 to 10 mcg/mL10 mcg/mL is 4 to 6 times the trough plasma concentration observed in the controlled efficacy trialsBecause lamotrigine is not highly bound to plasma proteinsclinically significant interactions with other drugs through competition for protein binding sites are unlikelyThe binding of lamotrigine to plasma proteins did not change in the presence of therapeutic concentrations of phenytoinphenobarbitalor valproateLamotrigine did notdisplaceotherAEDs(carbamazepinephenytoinphenobarbitalfrom protein-binding sites.

Other drugs may interact with lamotrigineincluding prescription and over-the-counter medicinesvitaminsand herbal productsTell your doctor about all your current medicines and any medicine you start or stop using.

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however, the relatively limited treatment experience with lamictal xr makes it difficult to characterize the frequency and risk of serious rashes caused by treatment with lamictal xr.

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