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SEARCH STRATEGYThe reviewers undertook electronic searches of Biological Abstracts1980-1999The Cochrane LibraryIssue 21999The Cochrane Schizophrenia Group’s RegisterSeptember 1999EMBASE1980-1999MEDLINE1966-1999and PsycLIT1974-1999References of all identified studies were searched for further trialsand the reviewers contacted relevant pharmaceutical companies and authors of trials.

The starting dose and dose range need not be routinely altered for non-smokers relative to smokersThe metabolism of olanzapine may be induced by smokingClinical monitoring is recommended and an increase of olanzapine dose may be considered if necessarysee section 4.5

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for the sleep disturbance when i gave up olanzapine completely, i also tried having a small glass of red wine in the evening before bed for a few weeks which i found helps with sleep as long as you don t drink too much and remember to stop drinking after a few weeks, when the withdrawal is over.


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