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In the treatment of fibrocystic breast disease, danazol usually produces partial to complete disappearance of nodularity and complete relief of pain and tenderness.

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Danazol has been used to treat women with endometriosis since the 1970s1It was the most commonly used drug in the early 1980sbut its use declined markedly after the introduction of the GnRH agonists in the late 1980s and early 1990s.

Experience with long-term therapy with Danazol is limitedPeliosis hepatis and benign hepatic adenoma have been observed with long-term usePeliosis hepatis and hepatic adenoma may be silent until complicated by acutepotentially life-threatening intra-abdominal hemorrhageThe physician therefore should be alert to this possibilityAttempts should be made to determine the lowest dose that will provide adequate protectionIf the drug was begun at a time of exacerbation of hereditary angioneurotic edema due to traumastress or other causeperiodic attempts to decrease or withdraw therapy should be considered.

In most instancesbreast pain and tenderness are significantly relieved by the first month and eliminated in 2 to 3 monthsUsually elimination of nodularity requires 4 to 6 months of uninterrupted therapyRegular menstrual patternsirregular menstrual patternsand amenorrhea each occur in approximately one-third of patients treated with 100 mg of DanazolIrregular menstrual patterns and amenorrhea are observed more frequently with higher dosesClinical studies have demonstrated that 50of patients may show evidence of recurrence of symptoms within one yearIn this eventtreatment may be reinstated.

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the mean half-life of danazol in healthy males is 9.


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