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Increased platelet count decreased levels of antithrombin IIIand increased plasminogen antigen and activity.
The Women’s Health InitiativeWHIestrogen-alone substudy reported increased risks of stroke and deep vein thrombosisDVTin postmenopausal women50 to 79 years of ageduring 7.1 years of treatment with daily oral conjugated estrogensCE0.625 mgalonerelative to placebosee WARNINGS AND PRECAUTIONSand Clinical Studies
14.Women with pre-existing hypertriglyceridemia should be followed closely during estrogen replacement or hormone replacement therapysince rare cases of large increases of plasma triglycerides leading to pancreatitis have been reported with estrogen therapy in this condition.
PREMARINconjugated estrogensVaginal CreamEach gram contains 0.625 mg conjugated estrogensUSP.
Estrogens increase thyroid-binding globulinTBGleading to increased circulating total thyroid hormoneas measured by protein-bound iodinePBIT 4 levels by column or by radioimmunoassay or T 3 levels by radioimmunoassayT 3 resin uptake is decreasedreflecting the elevated TBGFree T 4 and free T 3 concentrations are unaltered.
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treatment of overdose consists of discontinuation of premarin therapy with institution of appropriate symptomatic care.
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