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The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotoninExamples include street drugs such as MDMAecstasyStJohn’s wortcertain antidepressantsincluding SSRIs such as fluoxetine/paroxetineSNRIs such as duloxetine/venlafaxineamong othersThe risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs.
This drug passes into breast milk in small amountsConsult your doctor before breast-feeding.
The more commonly observed adverse reactions have included those of pressure sensationflushingtinglingdizziness/vertigowarm/hot sensationburning sensationflushingand numbnessformulation specific events including injection site reactionsapplication site painand nasal discomfort have been reportedRef]
Because clinical trials are conducted under widely varying conditionsadverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice.
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