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The cdc states that cefixime has an antimicrobial spectrum similar to that of ceftriaxone, but the 400-mg oral cefixime dose does not provide bactericidal concentrations that are as high and sustained as those provided by a 125-mg im dose of ceftriaxone.

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Cephalosporins may be associated with a fall in prothrombin activitypatients with renal or hepatic impairmentor poor nutritional statepatients receiving a protracted course of antimicrobial therapyand patients previously stabilized on anticoagulant therapymonitor prothrombin time in patients at risk and exogenous vitamin K administered as indicated.

6 months to 12 yearsweighing 45 kg or lessOral suspensionchewable tablets8 mg/kg orally once a day or 4 mg/kg orally every 12 hours.

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