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Patients with long-term kidney disease cannot eliminate phosphate from their bodiesThis leads to hyperphosphataemiawhichin the long termcan cause complications such as heart and bone diseaseThe active substance in Renagelsevelamer hydrochlorideis a phosphate binderWhen taken with mealsit attaches to phosphate from food within the gutpreventing it from being absorbed into the bodyThis helps to reduce the phosphate levels in the blood.

Renagel must not be used in people with hypophosphataemialow blood phosphate levelsor with bowel obstructiona blockage in the gut

If you need more information about your medical condition or your treatmentread the package leafletalso part of the EPARor contact your doctor or pharmacistIf you want more information on the basis of the CHMP recommendationsread the scientific discussionalso part of the EPAR

A clinical study in patients receiving peritoneal dialysisn=143found the most frequently occurring treatment emergent serious adverse reaction was peritonitisPeritonitis occurred in 8 patients receiving sevelamer and 2 patients on active controlRef]

Closer monitoring of patients with hypothyroidism co-administered with sevelamer hydrochloride and levothyroxine is recommendedsee section 4.5

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