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Triamterene and quinidine have similar fluorescence spectrathus MAXZIDEtriamterene and hydrochlorothiazidemay interfere with the measurement of quinidine.

Hydrochlorothiazide was orally administered to pregnant mice and rats during respective periods of major organogenesis at doses up to 3000 and 1000 mg/kg/dayrespectivelyAt these doseswhich are multiples of the MRHD equal to 3000 for mice and 1000 for ratsbased on body-weightand equal to 282 for mice and 206 for ratsbased on body-surface areathere was no evidence of harm to the fetusThere arehoweverno adequate and well controlled studies in pregnant womenBecause animal reproduction studies are not always predictive of human responsethis drug should be used during pregnancy only if clearly needed.

No specific data are available regarding MAXZIDEtriamterene and hydrochlorothiazideoverdosage in humans and no specific antidote is available.

Central Nervous Systemdrowsiness and fatigueinsomniaheadachedizzinessdry mouthdepressionanxietyvertigorestlessnessparesthesias.

Severe sweatingdiarrheaor vomiting can increase the risk for a serious loss of body waterdehydrationReport prolonged diarrhea or vomiting to your doctorTo prevent dehydrationdrink plenty of fluids unless your doctor directs you otherwise.

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